A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome c Exit

• DOI: 10.1128/spectrum.01066-23
• Publication Date: 2023-04-10T14:02:07Z
• Authors: Marianne Martin; Angelique deVisch; Yves-Marie Boudehen; Philippe Barthe; Claude Gutierrez; Obolbek Turapov; Talip Aydogan; Laurène Heriaud; Jerome Gracy; Olivier Neyrolles; Galina V. Mukamolova; François Letourneur; Martin Cohen-Gonsaud
• Keywords: mitochondria; Host-Pathogen Interactions; apoptosis; Humans; Cytochromes c; Tuberculosis; Mycobacterium tuberculosis; Energy Metabolism; metabolism; Microbiology; QR1-502; Research Article; Mitochondria

In this article, using a combination of techniques (bioinformatics, structural biology, and cell biology), we identified and characterized a new class of effectors present only in intracellular mycobacteria. These proteins specifically target host cell mitochondria when ectopically expressed in cells.