Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil

• DOI: 10.1128/spectrum.01163-21
• Publication Date: 2021-12-01T10:30:31Z
• Authors: Allyson G. Costa; Brenda K. S. Carv...; Mariana Araújo-Pe...; Hiochelson N. S. ...; Renata Spener-Gomes; Alexandra B. Souza; Adriano Gomes-Silva; Alice M. S. Andrade; Elisangela C. Silva; María B. Arriaga; Aline Benjamin; Michael S. Rocha; Adriana S. R. Mor...; Jamile G. Oliveira; Marina C. Figueiredo; Megan M. Turner; Betina Durovni; Solange Cavalcante; Afranio L. Kritski; Valeria C. Rolla; Timothy R. Sterling; Bruno B. Andrade; Marcelo Cordeiro-...
• Keywords: Quality Control; 0301 basic medicine; Enzyme-Linked Immunosorbent Assay; Microbiology; Specimen Handling; Cohort Studies; QuantiFERON-Plus; 03 medical and health sciences; Latent Tuberculosis; Humans; Mass Screening; Tuberculosis; Prospective Studies; quality control; IGRA; screening; Reproducibility of Results; Mycobacterium tuberculosis; LTBI; QR1-502; 3. Good health; tuberculosis; Brazil; Interferon-gamma Release Tests; Research Article

The IGRA has emerged as a useful tool for identifying persons with LTBI. Although the implementation of IGRAs is of utmost importance, to our knowledge there is scarce information on the identification of logistical and technical challenges for systematic screening for LTBI on a large scale.