Clinical and Microbiological Characteristics of Mycobacterium kansasii Pulmonary Infections in China

• DOI: 10.1128/spectrum.01475-21
• Publication Date: 2022-01-12T15:34:56Z
• Authors: Yinjuan Guo; Yanhua Cao; Haican Liu; Jinghui Yang; Weiping Wang; Bingjie Wang; Meilan Li; Fangyou Yu
• Keywords: Mycobacterium kansasii; rpoB

Mycobacterium kansasii, an important opportunistic pathogen of humans, causes serious pulmonary disease. Sixty M. kansasii isolates were collected for investigating the clinical characteristics patients with infections as well drug susceptibility and genotypes kansasii. More than 90% infected from eastern China. According to internal transcribed spacers (ITS), rpoB, hsp65, tuf, all classified molecular type I, irrespective disease manifestation. China diverse separated into four branches. Pairwise average nucleotide identity (ANI) values affiliated different more 85%. The earliest isolate was isolated Jiangsu in 1983. Of isolates, 78.3% (47/60) since 1999. All sensitive rifabutin. but one clarithromycin. Sensitivity rates rifampin, amikacin, moxifloxacin, linezolid 80.0%, 90.0%, 88.3%, 91.7%, respectively. A high rate resistance noted ciprofloxacin (44 73.3%) ethambutol (46 76.7%). Compared tuberculosis H37Rv, 12 mutations embCA observed isolates. these 60 shared identical sequences inhA, katG, rrl, rrs, rpsL, gyrA, gyrB. In conclusion, are exhibiting greater genetic diversity globally. mechanism is not necessarily related gene mutation. IMPORTANCE I main genotype spreading worldwide. history global spread remains largely unclear. We conducted a detailed analysis genomic evolution Our results suggest that exhibit