Multi-Omics Analysis Reveals the Protection of Gasdermin D in Concanavalin A-Induced Autoimmune Hepatitis

• DOI: 10.1128/spectrum.01717-22
• Publication Date: 2022-08-16T13:03:31Z
• Authors: Kaicen Wang; Wenrui Wu; Xianwan Jiang; Jiafeng Xia; Longxian Lv; Shengjie Li; Aoxiang Zhuge; Zhengjie Wu; Qiangqiang Wang; Shuting Wang; Lanjuan Li
• Keywords: Lipopolysaccharides; 0301 basic medicine; Glutamine; Glycerophospholipids; Microbiology; Mice; Interferon-gamma; 03 medical and health sciences; RNA, Ribosomal, 16S; Concanavalin A; Animals; Transaminases; Inflammation; autoimmune hepatitis; gut microbiota; Tumor Necrosis Factor-alpha; gasdermin D; Interleukin-17; QR1-502; 3. Good health; Toll-Like Receptor 4; intestinal barrier; Hepatitis, Autoimmune; Liver; metabolome; Research Article

Our study provides the first direct clues to the protective role of gasdermin D (GSDMD) in autoimmune hepatitis (AIH). We demonstrated thatGsdmdknockout exacerbated concanavalin A (ConA)-induced AIH in mice.