Polyproline Peptide Aggregation with Klebsiella pneumoniae Extracellular Polysaccharides Exposes Biofilm Associated Bacteria

• DOI: 10.1128/spectrum.02027-21
• Publication Date: 2022-03-07T16:02:09Z
• Authors: Renee M. Fleeman; Bryan W. Davies
• Keywords: 0301 basic medicine; capsule; Polysaccharides, Bacterial; Microbiology; biofilm; QR1-502; Klebsiella Infections; 3. Good health; Klebsiella pneumoniae; 03 medical and health sciences; Polysaccharides; Biofilms; exopolysaccharide; Humans; biofilms; Peptides; polyproline peptide; Bacterial Capsules; Research Article; Antimicrobial Cationic Peptides

Klebsiella pneumoniae bacterial infections are a major threat to human health as mortality rates are steadily on the rise. A defining characteristic of K. pneumoniae is the robust polysaccharide capsule that aids in resistance to the human immune system.