Transcriptome Analysis of Arcobacter butzleri Infection in a Mucus-Producing Human Intestinal In Vitro Model

• DOI: 10.1128/spectrum.02071-22
• Publication Date: 2023-01-09T09:46:08Z
• Authors: Davide Buzzanca; Valentina Alessan...; Cristian Botta; Negin Seif Zadeh; Ilario Ferrocino; Kurt Houf; Luca Cocolin; Kalliopi Rantsiou
• Keywords: Arcobacter; 0301 basic medicine; Virulence; Virulence Factors; Gene Expression Profiling; Arcobacter butzleri; virulence genes; Biology and Life Sciences; Microbiology; QR1-502; 3. Good health; 03 medical and health sciences; Animals; Humans; Arcobacteraceae; RNA-seq; Caco-2 Cells; transcriptome; Arcobacter butzleri; Arcobacteraceae; RNA-seq; transcriptome; virulence genes; Research Article

Recent advancements in the genomic characterization of A. butzleri revealed putative virulence genes and highlighted the possible pathogenic mechanisms used by this foodborne pathogen. It is therefore possible to study the transcriptomes of these bacteria to explore possible virulence mechanisms under conditions that mimic the infection process.