Characterization of Phage Resistance and Their Impacts on Bacterial Fitness in Pseudomonas aeruginosa

• DOI: 10.1128/spectrum.02072-22
• Publication Date: 2022-09-21T13:01:12Z
• Authors: Na Li; Yigang Zeng; Mengran Wang; Rong Bao; Yu Chen; Xiaoyu Li; Jue Pan; Tongyu Zhu; Bijie Hu; Demeng Tan
• Keywords: HMGA Proteins; 0301 basic medicine; Homogentisate 1,2-Dioxygenase; phage therapy; UTP-Glucose-1-Phosphate Uridylyltransferase; Bacteria; O Antigens; Microbiology; QR1-502; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; phage resistance; phage-host interactions; Pseudomonas aeruginosa; Bacteriophages; Research Article

Battling phage resistance is one of the main challenges faced by phage therapy. To overcome this challenge, detailed information about the mechanisms of phage-host interactions is required to understand the bacterial evolutionary processes.