The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response

• DOI: 10.1128/spectrum.02080-22
• Publication Date: 2022-10-20T14:26:45Z
• Authors: Anne-Emmanuelle Roux; Sylvie Robert; Mathilde Bastat; Isabelle Rosinski...; Vanessa Rong; Sébastien Holbert; Laurent Mereghetti; Emilie Camiade
• Keywords: 0301 basic medicine; 570; group B Streptococcus; Usp proteins; 610; adaptation; Microbiology; Streptococcus agalactiae; stress; 03 medical and health sciences; Bacterial Proteins; oxidative stress; MESH: Staphylococcal Protein A; Humans; Staphylococcal Protein A; MESH: Bacterial Proteins; carbon catabolite repression (CCR); catabolite repression; MESH: Gene Expression Regulation, Bacterial; MESH: Humans; MESH: Infant, Newborn; Bacterial; Infant, Newborn; stress response; Gene Expression Regulation, Bacterial; CcpA; Newborn; MESH: Gene Expression Regulation; MESH: Infant; MESH: Streptococcus agalactiae; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; QR1-502; stress adaptation; DNA-Binding Proteins; Repressor Proteins; Female; [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; acid resistance; MESH: Female; Research Article

Streptococcus agalactiae is a major cause of disease burden leading to morbidity and mortality in neonates worldwide. Deciphering its adaptation mechanisms is essential to understand how this bacterium manages to colonize its host. Here, we determined the regulon of the pleiotropic regulator CcpA in S. agalactiae . Our findings reveal that CcpA is not only involved in carbon catabolite repression, but is also important for acidic and oxidative stress resistance and survival in macrophages.