Elevating fungal care: bridging Brazil’s healthcare practices to global standards

• DOI: 10.1128/spectrum.02112-24
• Publication Date: 2025-03-10T13:01:51Z
• Authors: Jon Salmanton-García; Diego R. Falci; Oliver A. Cornely; Alessandro C. Pas...; ; Afonso L. Barth; David W. Denning; Fernando Riera; Sergio Cimerman; Arnaldo L. Colombo; Valerio R. Aquino; Antonio Vena; Volkan Özenci; Katrien Lagrou; Sevtap Arikan-Akd...; Ana Alastruey Izq...; Esther Segal; Jean-Pierre Gangneux; Martin Hoenigl; Vasilika Mano; Anahit Zakharyan; Diana Soghomonyan; Helmut J.F. Salzer; Birgit Willinger; Ravil Hseyn; Naila Mammadova; Anastasiya Sidarenka; Sviatlana Kandaurava; An Boel; Geert Vanheule; Marijke Reynders; Philippe Clevenbergh; Ann Packeu; Deborah Degeyter; Yarah Overmeire; Jerina Boelens; Louis Ide; Reinoud Cartuyvels; Anne-Isabelle de ...; Nathalie Layios; Truus Goegebuer; Peter Verbeeck; Maja Travar; Amela Dedeić Ljub...; Ivan Malkodanski; Diana Dimova; Tsvetelina Velikova; Ivva Philipova; Sabina Cviljevic; Jasmina Kučinar; Maja Abram; Ivanka Matas; Andrea Janes; Maja Šegvić Klarić; Suzana Bukovski; Ljiljana Cicmak S...; Ana Čičmak; Christos Karagiannis; Martina Lengerová; Petr Hamal; Radim Dobiáš; Vanda Chrenkova; Pavlina Lyskova; Zdeněk Ráčil; Turid Snekloth Sø...; Lise Kristensen; Birgitte Smith; Maiken Cavling Ar...; Flemming Schønnin...; Jens Jørgen Chris...; Kaisa Kirs; Linda Pirozkova; Helle Järv; Marika Jürna-Ellam; Krista Lõivukene; Nathalie Friberg; Jari Kauranen; Laura Billon; Yohann Le Govic; Jean-Philippe Bou...; Véronique Blanc; Gaetan Plantefeve; Laurence Millon; G Laurent; Sophie Brun; Frédéric Gabriel; Solène Le Gal; Julie Bonhomme; Philippe Poirier; Guillemette Fouquet; Françoise Botterel; Frederic Dalle; Cécile Garnaud; Helene Pelerin; Boualem Sendid; Marie-Fleur Durieux; Jean Menotti; Stéphane Ranque; Franck Labbé; Laurence Lachaud; Florent Morio; Lilia Hasseine; Milène Sasso; Laura Courtellemont; Alexandre Alanio; Marie-Elisabeth B...; Christophe Hennequin; Jacques Cadranel; Arnaud Fekkar; Eric Dannaoui; Christine Bonnal; Estelle Perraud-C...; Antoine Huguenin; Damien Costa; Marcela Sabou; Frederic Janvier; Sophie Cassaing; Guillaume Desoubeaux; Edith Mazars; Tamar Didbaridze; Lile Malania; Jürgen Bohnert; Gerhard Haase; Tatjana Buchberger; Stefan Schwartz; Antonia Sassmann-...; Lutz von Müller; Jürgen Held; Thomas Lehrnbecher; Michael Kiehl; Janina Trauth; Anna Dudakova; Maria Schröder; Ludwig Sedlacek; Sabrina Klein; Soeren Becker; Helmut Fickenscher; Oliver Schildgen; Benigno Florido P...; Sandra Gräber; Lukas Eberwein; Susanne Hauswaldt; Enrico Schalk; Andreas Groll; Meinolf Karthaus; Tobias Lahmer; Karl Dichtl; Joerg Steinmann; Anja Berger; Axel Hamprecht; Matthias Vöhringer; Michaela Simon; Micha Lobermann; Michael Schmid; Gregor Paul; Annika Schmidt; Martina Furitsch; Beniam Ghebremedhin; Oliver Kurzai; Maria Panopoulou; Georgia Vrioni; Joseph Meletiadis; Angeliki Stathi; Sofia Maraki; Konstantina Gartz...; Despoina Gkentzi; Emmanuel Roilides; Charalampos Mandros; Eszter Vad; László Majoros; Agnes Sonnevend; Ilona Dóczi; Ingibjorg Hilmars...; Shomik Sibartie; Niamh O'Sullivan; Sam McConkey; Alida Fe Talento; Binu Dinesh; Brian O'Connell; Breda Lynch; Patrick Stapleton; Ilana Oren; Eli Ben Chetrit; Maya Korem; Shifra En-Dror; Alkrenawi A'laa; Ronen Ben-Ami; Rosa Monno; Caterina Buquicchio; Claudio Farina; Michele Bartoletti; Chiara Cattaneo; Goffredo Angioni; Mario Virgilio Papa; Malgorzata Mikulska; Elio Castagnola; Patrizia Danesi; Annarosa Cuccaro; Orazio Romeo; Chiara Oltolini; Anna Grancini; Spinello Antinori; Gianluigi Lombardi; Fabio Forghieri; Alberto Enrico Ma...; Nicola Coppola; Federico Itri; Andrea Cortegiani; Lucia Prezioso; Katia Perruccio; Francesco Barchiesi; Giuliana Lo Cascio; Giammarco Raponi; Francesco Marchesi; Maria Ilaria Del ...; Elena De Carolis; Maria Calabrò; Silvana Sanna; Vivian Tullio; Simone Mornese Pinna; Alessandro Busca; Assunta Sartor; Mario Cruciani; Gianpaolo Nadali; Anna Azzini; Aferdita Kurti Meta; Solvita Selderina; Māris Pabērzs; Zygimantas Alsauskas; Diana Zilyte; Silvija Kiveryte; Stephen Decelis; Oxana Munteanu; Lidija Maslovar; Karin van Dijk; Jaap van Doesum; Claudy Oliveira d...; Peter Croughs; Pieter-Jan Haas; Ferry Hagen; Gordana Mirchevska; Nora Nyquist; Lisa Valle; Cecilie Torp Ande...; Kjersti Wik Larssen; Jan Styczynski; Iwona Żak; Monika Biernat; Iwona Wodzinska M...; Joana Batista; Elmano Ramalheira; Antonio Guerra Maio; Agostinho Carvalho; Rui Tomé; Adriana Coutinho; Dinah Carvalho; Cristina Toscano; Augusto Machado e...; Raquel Sabino; Zélia Videira; Virginia Monteiro; Virgínia Lopes; Elmira Ibraim; Vlad Jeni Laura; Maria Nica; Serban Elena Daniela; Floredana Sular; Natalia Minaeva; Anastasiya Aleksa...; Anastasiia Galina...; Galina Solopova; Tatiana V. Gorbunova; Maria Efinova; Vladimir Ivanov; Anastasiya Kuzyaeva; Alisa Volkova; Marina Popova; Elena P. Barantse...; Nikolai Klimko; Julia Sveshnikova; Eleonora Dubljanin; Biljana Lazović-P...; Aleksandra Barac; Branislava Milenk...; Slavica Dacic; Marina Sokovic; Valentina Arsic A...; Tatjana Adzic Vuk...; Suzana Otašević; Zuzana Beckova; Lubos Drgona; Lubomir Sojak; Miroslava Pőczová; Anna Liskova; Viktorija Tomic; Miha Skvarc; Tadeja Matos; Oscar Fraile Santos; Antonia Calvo Cano; Gema Fernandez Rivas; Maria Teresa Mart...; Ferran Sanchez Reus; Celia Cardozo; Marta Lamata Subero; Rocío Tejero; Miriam Alkorta; Gemma Jiménez Guerra; Fernando Cobo; Irati Ormazabal V...; Carolina Roldán-F...; Luis Ros Vidal; Raul Gilarranz; Alfredo Jover-Sáenz; Elia Gomez; Julio Garcia Rodr...; Ana Perez de Ayala; Alberto García-Sa...; Maricela Valerio; Ana Fernández Cruz; Leovigildo Ginel ...; Maria Teresa Pelá...; Lourdes Vazquez; Rocio Kohan; Ianire Virto Peña; Maria Pía Roiz Me...; Rocio Trastoy Pena; Ana Isabel Suárez; Maite Ruiz; Alicia Beteta López; Frederic Gómez Be...; Javier Peman; Tomas Garcia Lozano; David Navarro Ortega; Concepcion Lopez ...; Nahid Kondori; Lena Serrander; Karl Oldberg; Martin Sundqvist; Nina Kamenska; Beatrice Widman; Eva Hålldin; Oskar Ekelund; Daniel Goldenberger; Stefan Zimmerli; Arnaud Riat; Alix T. Coste; Christoph Weissert; Andrea Zbinden; Macit Ilkit; Hatice Hale Gümüş; Berrin Esen; Ali Korhan Sig; Yasemin Tezer; Ayse Kalkanci; Guldane Cengiz Seval; Filiz Kizilates; Dilara Ogunc; Gulden Eser Karlidag; Nurettin Erben; Arzu Yetkin; Gul Ruhsar Yilmaz; Demet Haciseyitoglu; Aydin Aydinli; Yasemin Cag; Uluhan Sili; Onder Ergonul; Seda Yilmaz Semerci; Süleyha - Hilmioğ...; Esma Eren; Benhur Cetin; Mustafa Altindids; Mehmet Reşat Ceylan; Serhii Liashenko; Olga Sych; Sergiy Klymenko; Deborah Lockhart; Hytham K. S. Hamid; Andrew Borman; Lewis White; Alison Walworth; Abhijit Bal; Richard Hobson; Richard Barton; Tihana Bicanic; Jonathan Lambourne; Neil Stone; Darius Armstrong-...; Rebecca Gorton; Alireza Abdolrasouli; Nita Fatania; Avinash Aujayeb; David Partridge; Bob Phillips; Cornelia Lass-Flörl; Stephane Bretagne; Peter-Michael Rath; Jacques F Meis; Riina Richardson; Sanja Pleško; Anat Stern; Abhijit Bal; Ana Ramalhinho; Adilia Warris; Aferdita Berisha ...; Ajete Aliu-Bejta; Sevim Akçağlar; Alba Ruiz; Alberto López García; Alessandra Bandera; Alessandra Tucci; Alexander Veselov; Alexandre Mzabi; Alexander Halfmann; Alexander Link; Alexandra Bakossi; Alina Daniela Tanase; Amela Dedeic Ljub...; Alessandra Mularoni; Ana Álvarez-Uría; Ana Rita Tavares; Andrea Cortegiani; Andres Ceballos; Andrew Ustianowski; Anna Camaggi; Anna Goer; Anne-Lise Munier; Annette Onken; Ann-Katrin Svensson; Antoine Adenis; Antonio Ruggiero; Anu Tamm; Alen Ostojic; Ivan Pchelin; Arsim Kurti; Astrid Muyldermans; Athanasios Chatzi...; Athanasios Tragia...; Augusta Gonçalves; Auveen Griffin; Aviva Dudi; Aviva Dudi; Timoleon-Achillea...; Axel Hamprecht; Ayşe Barış; Azniv Gevorgyan; Bruno Francois; Begoña Carazo Gal...; Beatriz Plata Barril; Besmira Zama; María Belén Herná...; Børge Førland Gjøse; Botond Lakatos; María José Buitrago; Corinne Andreutti; Caterina Cavanna; Campbell Gourlay; Carmen Aldea Mansila; Claire Lacroix; Carlos Grasa; Carlos Ruiz de Al...; Carmen Pazos; Catarina Gouveia; Chouaki Taieb; Christian S. Haas; Christina Bahrs; Claudia Crowell; Clare Logan; Coral Garcia Esteban; Cristina Veríssimo; Carsten Suhr Jaco...; Dace Rudzite; Damien Dupont; Daniela Lzicarova; Dea Garcia-Hermoso; Michal Dekel; Margherita De Masi; Yulia Dinikina; Daniela Jaksic; Donjeta Pllana-Ha...; Donjeta Pllana-Ha...; Despo Pieridou; Alina Teliuk; Magdalena Baymakova; Georgi Tsigarovski; Ivan Tyanev; Krasimir Donchev; Lidiya Nikolcheva...; Zeynep Memiş; Danica Milobratović; Nagehan Didem Sagı; Lidija Ljubisa-Ma...; Deniz Yilmaz Kara...; Eoin Feeney; Eavan Muldoon; Ecaterina Noroc; Encarnación Clavi...; Eoghan De Barra; Edmond Puca; Ela Clavel; Elchin Mirzezade; Elena Busch; Elham Khatamzas; Elizabeth Johnson; Elodie Couvé-Deacon; Elodie Pernot; Henrik Elvang Jensen; Emmanuel Edwar Si...; Eric Levesque; Eric Nulens; Erja Chryssanthou; Eva Alcoceba Crui...; Fabio Gualtieri; Iker Falces-Romero; Francesca Farina ...; Fatih Demirkan; Fátima Galán-Sánchez; Felix Goeser; Flávia Cunha Flor...; Florian Reizine; Francesc Marco; Francesca Gioia; Franziska Ebeling; Frieder Fuchs; Frieder Schaumburg; Fuat H. Saner; George Dimopoulos; Gema Fernández Rivas; Gintaras Makstutis; Giulia Morganti; Lior Haftel; Arjan Harxhi; Helena Hammarström; Helmut Ostermann; Helmut Schweiger; Henrik Grigoryan; Hovhannes Hovhann...; Claus Peter Heußel; Isabel Antorrena-...; Igor Aurer; Ivana Mareković; Ingvild Nordøy; Irina Lysenko; Irena Zdovc; Maria Isabel Sánc...; Isik Somuncu Joha...; Iva Košćak; Isabelle Villena; Jolanta Miciulevi...; John Moore; Julia J; José María Aguado; Jakub Hurych; Jan Novák; Janos Sinko; Jochen Brasch; Javier Colomina; Jaroslaw Dybko; Jean-Jacques Tudesq; Jelena Todorovic; Jens Van Praet; Julio García Rodr...; Jannik Helweg-Larsen; Jose L. Blanco; Jose Miguel Cisneros; Jochem Buil; Johan Maertens; Johanne Haugen; Jolien Claessens; Joaquim Oliveira; José F. Cano; Miguel Montejo; Josué Pendones Ul...; József Pauer; Juan Ramón Gómez ...; Juergen Prattes; Jürgen Rödel; Julia Hoveyan; Juliane Brandt; Julien de Greef; Juliette Guitard; Joanna Zawitkowska; Kadri Kermes; Karel Maelegheer; Karin Bohman; Karin Kindlund; Karsten Becker; Csaba Kassa; Kata Martinova; Nathan Keller; Kerstin Arndt; Iva Kocmanová; Kristis Vevis; Kseniia Bolharina; Lars Kleppe; Laura Ferreras; Laura Marques; Lena Klingspor; Letizia Fracchia; Linda Bussini; Lionel Fontao; Lisset Lorenzo de...; Leander Köpnick; Laura Marques; Lóránt Hatvani; Lotus Marcus; Lothar Wiese; Elisabeth Paramyt...; Lucrecia Yáñez; Luisa Verga; Lusine Paronyan; Dolores Pinheiro; Mariam Fahradyan; Maddalena Giannella; Mahasin Al Shakirchi; Maja Abram; Murat Akova; Malcolm Richardson; Mansour Ceesay; Vardges Avagyan; Marc Froissart; Marcella Sibani; María Siller; Margarida Tavares; Carmen Martinez R...; Marianna Criscuolo; Marina Machado; Mario Fernández Ruiz; Maria Siopi; Martha Oberschelp; Martin Hoenigl; Maurizio Sanguinetti; Marina Demchenkova; Michael Palmer; Michaela Lackner; Mihai Mares; Milan Navratil; Milos Petrik; Pasqua Betta; Magdalena Namysł; Miguel Cacho Teixe; Modar Saleh; Mohamed Douedari; Monique Ameyo Dor...; Marie-Pierre Ledoux; Marie-Pierre Hayette; Maja Šegvić Klarić; Marc Stadler; Muriel Nicolas; Nadine Dietze; Naieya Nargiza; Nargiza Davletshina; Natalia Lisita; Nathalie Wilhelm; Nərgiz İsmayıllı; Lior Nesher; Nicola Stefano Fr...; Nicole Desbois-No...; Nina Gunde-Cimerman; Nina Khanna; Popescu Oana; Ozren Jaksic; Ola Blennow; Peter Olbrich; Olimpia Finizio; Olga V. Shadrivova; Olive Murphy; Oksana Glukhareva; Özlem Alhan Güncü; Patrizia Zappasodi; Miriam Parizade; Patrice Le Pape; Paul Verweij; Paula Martins da ...; Paula Kell; Paulo Pereira; Philipp Bosshard; Philipp Koehler; Philippe Montravers; Piera Anna Martino; Pilar Robles; Peter-Michael Rath; Patricia Muñoz; Przemyslaw Zdziarski; Pere Soler-Palacín; Quilez Malo Casero; Raili Randoja; Rebeca Rodríguez ...; Rodrigo Martino; Rasmus Krøger Hare; Robert Krause; Rodica Golban; Jelena Roganovic; Roger Bruggemann; Roxana Munteanu; Rui Bergantim; Rui Soares; Susanne Elsner; Barbora Weinberge...; Walter Geißdörfer; Elena Shagdileeva; Sebastien Imbert; Jan Springer; Paraskevi Mantzana; Rina Segal; Samir Javadov; Sara Gago Samvel; Timo Schmitt; Selma Olsson Åkef...; Silva Tafaj; Simone Cesaro; Sofia de la Villa; Sofia Alexandru; Sofia Costa de Ol...; Sofya Khostelidi; Stefan Büttner; Stefan Glöckner; Stephen Hawser; Susanne Woxenius; Teresa Maria Fasc...; Thomas Harrer; Toni Valković; Ülker Koçak; Valentina Maria M...; Vanya Gant; Varun Mehra; Varvara Solodovni...; Vega Zamora Fuente; Vladislav Kostin; Volha Mishkova; Waldo Sánchez-Yeb...; Wendy van de Sande; Werner Albrich; Willem Melchers; Yana Erdomaeva; Yasmin Maor; Zlate Stojanoski; Zoi Dorothea Pana; Zoya Ivanova; Zumrut Sahbudak Bal

ABSTRACT Brazil faces unique challenges in managing invasive fungal infections (IFIs) due to diverse ecosystems, a rural workforce, and prevalent health conditions. In Europe, IFIs are primarily associated with transplantation, intensive care, chronic diseases. Inspired by initiatives the Caribbean Latin America 2019, efforts map global diagnostic treatment resources expanded Africa, Asia/Pacific. This study conducts comparative analysis, mainly drawing data from investigate IFI epidemiology management. Data were collected through online surveys distributed Brazilian European institutions, collaborations scientific organizations. Surveys covered institutional profiles, diagnoses, accessibility techniques, antifungal drugs. A survey involving 96 388 institutions revealed variations perception practices related pathogens. Differences ranking prevalence observed, along procedures, fluorescence dye usage, culture practices, medication availability, technological approaches. Europe exhibited higher utilization rates for molecular approaches, including PCR tests, therapeutic drug monitoring (TDM) was more widespread compared Brazil, indicating substantial differences understanding infections. Customized management is crucial, considering regional addressing gaps like underutilized PCR. The advocates increased international collaboration, targeted training, enhanced foster unified approach preventing, diagnosing, treating IFI. IMPORTANCE work significant as it highlights its ecosystems public landscape. By comparing Brazil’s situation Europe—where linked transplantation care—this identifies key disparities practices. findings reveal availability use of diagnostics, drugs, monitoring, demonstrating advanced mapping these variations, underscores importance tailored approaches that consider gaps. Ultimately, calls resource allocation improve outcomes globally, particularly regions limited access tools treatments.