Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies

• DOI: 10.1128/spectrum.02486-22
• Publication Date: 2022-10-31T14:04:28Z
• Authors: Therese de Neergaard; Anna Bläckberg; Hanna Ivarsson; Sofia Thomasson; Vibha Kumra Ahnlide; Sounak Chowdhury; Hamed Khakzad; Wael Bahnan; Johan Malmström; Magnus Rasmussen; Pontus Nordenfelt
• Keywords: opsonization; binding; Streptococcus pyogenes; Bacteremia; invasive microorganisms; pyogenes; Microbiology; sepsis; 03 medical and health sciences; group a streptococcus; Phagocytosis; Streptococcal Infections; Humans; streptococcus pyogenes; bacteremia; Antigens, Bacterial; 0303 health sciences; region; phagocytosis; antibody response; sequence; Antibodies, Bacterial; QR1-502; 3. Good health; [SDV] Life Sciences [q-bio]; emm type; antigen specificity; m-protein; antibody function; Research Article

The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is still incomplete.