Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage

• DOI: 10.1128/spectrum.02504-22
• Publication Date: 2023-02-14T14:13:47Z
• Authors: Paula Faral-Tello; Gonzalo Greif; Selva Romero; Andrés Cabrera; Cristina Oviedo; Telma González; Gabriela Libisch; Ana Paula Arévalo; Belén Varela; José Manuel Verdes; Martina Crispo; Yester Basmadjián; Carlos Robello
• Keywords: Chagas Disease; Horizontal transmission; Transplacental

The main findings of this study are that we determined there Trypanosoma cruzi strains adapted to transplacental transmission and completely different from the commonly used laboratory reference strains. This implies a specific strategy for vertical Chagas disease.