NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo

• DOI: 10.1128/spectrum.02592-22
• Publication Date: 2022-10-31T14:04:46Z
• Authors: Padam Singh; Srishti Rawat; Ashish Kumar Agra...; Manisha Singh; Saurabh Chugh; Sudagar Gurcha; Albel Singh; Katherine Abrahams; Gurdyal S. Besra; Shailendra Asthana; Diwan S. Rawat; Ramandeep Singh
• Keywords: Benzaldehyde; Semicarbazone

Mycobacterium tuberculosis , the causative agent of TB is among leading causes death infectious diseases in humans. This situation has worsened due to failure BCG vaccines and increased number cases with HIV-TB coinfections drug-resistant strains.