A Leak-Free Inducible CRISPRi/a System for Gene Functional Studies in Plasmodium falciparum
0301 basic medicine
Resource Report
Plasmodium falciparum
Microbiology
QR1-502
Artemisinins
Epigenesis, Genetic
3. Good health
dCas9
Antimalarials
03 medical and health sciences
Gene Expression Regulation
DiCre
CRISPR-Cas Systems
gene regulation
human malaria
DOI:
10.1128/spectrum.02782-21
Publication Date:
2022-05-05T13:00:56Z
AUTHORS (10)
ABSTRACT
Understanding the fundamental biology of malaria parasites through functional genetic/genomic studies is critical for identifying novel targets for antimalarial development. Conditional knockout/knockdown systems are required to study essential genes in the haploid blood stages of the parasite.
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