A Leak-Free Inducible CRISPRi/a System for Gene Functional Studies in Plasmodium falciparum

0301 basic medicine Resource Report Plasmodium falciparum Microbiology QR1-502 Artemisinins Epigenesis, Genetic 3. Good health dCas9 Antimalarials 03 medical and health sciences Gene Expression Regulation DiCre CRISPR-Cas Systems gene regulation human malaria
DOI: 10.1128/spectrum.02782-21 Publication Date: 2022-05-05T13:00:56Z
ABSTRACT
Understanding the fundamental biology of malaria parasites through functional genetic/genomic studies is critical for identifying novel targets for antimalarial development. Conditional knockout/knockdown systems are required to study essential genes in the haploid blood stages of the parasite.
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