Exploring the Relevance between Gut Microbiota-Metabolites Profile and Chronic Kidney Disease with Distinct Pathogenic Factor

• DOI: 10.1128/spectrum.02805-22
• Publication Date: 2022-12-08T09:01:43Z
• Authors: Tso-Hsiao Chen; Chung-Yi Cheng; Chun-Kai Huang; Yi-Hsien Ho; Jung-Chun Lin
• Keywords: Metabolome; Clinical Significance

The intimate correlation of chronic kidney disease (CKD) with structural alteration in gut microbiota or metabolite profile has been documented a growing body studies. Nevertheless, paucity demonstrated knowledge regarding the impact and underlying mechanism on occurrence progression CKD is unclarified thus far. In this study, liquid chromatography coupled-mass spectrometry long-read sequencing were applied to identify metabolites microbiome statistically-discriminative abundance diabetic patients (n = 39), hypertensive 26), without comorbidity 40) compared those healthy participants 60). association between CKD-related species was evaluated by using zero-inflated negative binomial (ZINB) regression. predictive utility identified operational taxonomic units (OTUs), metabolite, species-metabolite toward diagnosis incident distinct pathogenic factor assessed random forest regression model receiver operating characteristic (ROC) curve. results statistical analyses indicated alterations relative abundances 26 OTUs 41 that specifically relevant each CKD-patient group. only species, metabolites, its differentially distinguished hypertensive, patients, enrolled from participants. IMPORTANCE Gut dysbiosis-altered exhibits specific convincing differentiate associated factor. These present validity pathogenesis-associated markers across high-risk population early screening, prevention, diagnosis, personalized treatment CKD.