Porcine Reproductive and Respiratory Syndrome Virus nsp1β Stabilizes HIF-1α to Enhance Viral Replication

• DOI: 10.1128/spectrum.03173-22
• Publication Date: 2022-11-23T14:02:37Z
• Authors: Yu Pang; Yanrong Zhou; Yuchen Wang; Zheng Sun; Jiao Liu; Chenyu Li; Shaobo Xiao; Liurong Fang
• Keywords: Replication

Porcine reproductive and respiratory syndrome virus (PRRSV) has devastated the swine industry worldwide for over 30 years shows no signs of slowing down. In this study, we found that PRRSV infection elevated hypoxia-inducible factor 1α (HIF-1α) expression.