Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis

• DOI: 10.1128/spectrum.03279-22
• Publication Date: 2023-01-18T14:00:50Z
• Authors: Patricia M. Lenha...; Kenneth C. Malcolm; Emily Wheeler; Noel M. Rysavy; Katie Poch; Silvia Caceres; Kara M. Calhoun; Stacey L. Martiniano; Jerry A. Nick
• Keywords: nontuberculous mycobacteria; opsonization; 0303 health sciences; Cystic Fibrosis; Neutrophils; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; complement C3; Complement System Proteins; Microbiology; QR1-502; 3. Good health; cystic fibrosis; 03 medical and health sciences; neutrophils; Immunoglobulin M; Opsonization; Humans; Research Article; Mycobacterium avium

Mycobacterium avium is a member of a group of bacterial species termed nontuberculous mycobacteria (NTM) that cause lung disease in certain populations, including persons with cystic fibrosis (CF). NTM infections are challenging to diagnose and can be even more difficult to treat.