The imbalance of pulmonary Th17/Treg cells in BALB/c suckling mice infected with respiratory syncytial virus-mediated intestinal immune damage and gut microbiota changes

• DOI: 10.1128/spectrum.03283-23
• Publication Date: 2024-05-10T13:00:44Z
• Authors: Jiling Liu; Yixuan Huang; Nian Liu; Huan Qiu; Xiaoyan Zhang; Xiaojie Liu; Maozhang He; Mingwei Chen; Shenghai Huang
• Keywords: 0303 health sciences; 03 medical and health sciences; gut microbiota; respiratory syncytial virus; IL-22; Microbiology; QR1-502; regenerating islet-derived protein; Research Article

ABSTRACT The immune response induced by respiratory syncytial virus (RSV) infection is closely related to changes in the composition and function of gastrointestinal microorganisms. However, specific mechanism remains unknown pulmonary-intestinal axis deserves further study. In this study, mRNA levels ROR-γt Foxp3 lung intestine increased first then decreased. IL-17 IL-22 reached maximum on third day after lung, second small colon, respectively. RegⅢγ intestinal tissue RSV infection. Moreover, genus enriched group was Aggregatibacter , Proteus reduced. not only causes Th17/Treg cell imbalance lungs mice but also leads release excessive from through blood circulation which binds receptors surface, inducing overexpression, impaired development, altered gut microbiota composition. Our research reveals a significant link between pulmonary IMPORTANCE most common pathogen causing acute lower tract infections infants young children, complex interactions system still requires research. it suggested that 7-day-old BALB/c suckling caused inflammation disruption cells overexpression RegⅢγ, leading injury microbiota. This may be gut. study provide new insight into symptoms other viruses connection axis, as well therapeutic ideas for treatment RSV-infected children.