Diverse Populations of Staphylococcus pseudintermedius Colonize the Skin of Healthy Dogs

• DOI: 10.1128/spectrum.03393-22
• Publication Date: 2023-02-14T14:25:13Z
• Authors: Norma Fàbregas; Daniel Pérez; Joaquim Viñes; Anna Cuscó; Lourdes Migura-Ga...; Lluís Ferrer; Olga Francino
• Keywords: Staphylococcus pseudintermedius; Colonisation; Staphylococcal Skin Infections

Staphylococcus pseudintermedius is a commensal bacterium of the canine skin but also key opportunistic pathogen that responsible for most cases pyoderma in dogs. The current paradigm indicates infection arises when predisposing factors alter healthy barrier. Despite their importance, characteristics S. populations colonizing dogs are yet largely unknown. Here, we retrieved 67 complete circular genomes and 19 associated plasmids from isolated 9 via long-reads Nanopore sequencing. Within skin, multilocus sequence typing (MLST) detected 10 different STs, distributed mainly by host. 39% 18 representative herein were methicillin-resistant (MRSP), they showed, on average, higher number antibiotic resistance genes prophages than did methicillin-sensitive (MSSP). In summary, our results revealed inhabiting relatively diverse heterogeneous terms MLST methicillin resistance. this study, all contained genes, indicating extent severity problem antimicrobial staphylococci with zoonotic potential.