Proteomic and Phenotypic Studies of Mycoplasma pneumoniae Revealed Macrolide-Resistant Mutation (A2063G) Associated Changes in Protein Composition and Pathogenicity of Type I Strains

• DOI: 10.1128/spectrum.04613-22
• Publication Date: 2023-06-28T14:00:14Z
• Authors: Zhikun Zhang; Haiwei Dou; Qing Yuan; Dawei Shi; Ruijie Wan; Peng Tu; Deli Xin; Shuilong Guo
• Keywords: Proteomics; Virulence; Caspase 3; proliferation; Interleukin-8; Microbial Sensitivity Tests; A2063G; Microbiology; QR1-502; 3. Good health; Mycoplasma pneumoniae; Anti-Bacterial Agents; adhesion; RNA, Ribosomal, 23S; proteomics; Drug Resistance, Bacterial; Mutation; Humans; Macrolides; Child; Research Article

The prevalence of macrolide-resistant MPs increased the difficulty in treatment of MP infections and posed potential threats to children's health. Epidemiological studies showed a high prevalence of IR-resistant strains (mainly A2063G in 23S rRNA) in these years.