Serotype Distribution and Antimicrobial Resistance of Streptococcus agalactiae Isolates in Nonpregnant Adults with Streptococcal Toxic Shock Syndrome in Japan in 2014 to 2021

• DOI: 10.1128/spectrum.04987-22
• Publication Date: 2023-02-14T14:28:41Z
• Authors: Tadayoshi Ikebe; Rumi Okuno; Yumi Uchitani; Mami Takano; Takahiro Yamaguchi; Hitoshi Otsuka; Yu Kazawa; Shohei Fujita; Ayaka Kobayashi; Yoshimi Date; Junko Isobe; Emi Maenishi; Makoto Ohnishi; Yukihiro Akeda; ; Keiko Ogawa; Kazuya Mitsuhashi; Takayuki Konno; Kaori Iwabuchi; Takuya Yamanaka; Junji Seto; Mikako Hosoya; Takuhiro Suto; Hiroo Sakai; Ikuo Ogawa; Mayumi Ogawa; Ayano Horikoshi; Miki Matsuyama; Yusuke Yodotani; Chieko Goto; Junko Yoshihara; Kentaro Tomari; Fumie Suzuki; Sae Onoda; Asami Sekikawa; Miki Hikida; Mitsuru Kishizawa; Haruyoshi Kanagawa; Akira Wakatsuki; Akihito Kobayashi; Yuhki Nagai; Tatsuya Matsuda; Higashi Ogura; Makiko Noda; Ayako Furuta; Emiko Kitagawa; Misa Yoshikawa; Mika Fujikawa; Etsuko Saito; Chikara Nakagawa; Noriko Nakanishi; Yuko Kiguchi; Kayoko Nakaoka; Kayo Aoki; Seiko Umehara; Ryutaro Murayama; Shoko Hirata; Kenkichi Hayashibara; Jun Kawase; Hisahiro Kawai; Takahiro Hiratsuka; Hiroko Akita; Chiiko Yoshida; Yuka Kakumiya; Yukiko Asano; Sayaka Osaki; Atsuko Kageyama; Yuji Migita; Yurika Furukawa; Rika Maeda; Etsuko Nakamura; Tetsuya Kakita; Tsuyoshi Kudeken
• Keywords: Toxic shock syndrome; Group B; Streptococcus Pyogenes; Group A

The incidence of streptococcal toxic shock syndrome (STSS) due to group B Streptococcus (GBS) has been increasing annually in Japan and is becoming a serious challenge. Furthermore, recent years, penicillin- or clindamycin-resistant strains used treating have reported. However, no report analyzed >100 isolates causing syndrome. Therefore, we aimed perform serotyping antimicrobial susceptibility testing 268 isolated from cases involving nonpregnant adult patients between 2014 2021. most prevalent serotype was Ib, followed by serotypes V, III, Ia. Seven were resistant penicillin G, 17.9% (48 isolates) clindamycin. Of the penicillin-resistant isolates, 71.4% (5 clindamycin resistant. In addition, with before these become prevalent, introduction vaccine essential for disease prevention.