Metabolite Alterations and Interactions with Microbiota in Helicobacter pylori-Associated Gastric Lesions

• DOI: 10.1128/spectrum.05347-22
• Publication Date: 2023-06-26T14:01:01Z
• Authors: Lei Peng; Yang Guo; Markus Gerhard; Juan-Juan Gao; Zong-Chao Liu; Raquel Mejías-Luque; Lian Zhang; Michael Vieth; Jun-Ling Ma; Wei-Dong Liu; Zhe-Xuan Li; Tong Zhou; Wen-Qing Li; Wei-Cheng You; Yang Zhang; Kai-Feng Pan
• Keywords: FOS: Computer and information sciences; Intestinal metaplasia; Bioinformatics; Biopsy; Metabolite; Nursing; FOS: Health sciences; Microbiology; Helicobacter Infections; Role of Fructans in Nutrition and Health; Endocrinology; Stomach Neoplasms; RNA, Ribosomal, 16S; Biochemistry, Genetics and Molecular Biology; Helicobacter; Health Sciences; Genetics; Humans; Metabolomics; Bacteroides; Gut Microbiota; gastric metabolites; Biology; Internal medicine; Nutrition and Dietetics; Helicobacter pylori; Bacteria; Microbiota; Gastroenterology; Life Sciences; Cell Biology; interactions; Fusobacterium; QR1-502; 3. Good health; gastric microbiota; Helicobacter pylori Infection and Gastric Cancer; Biological Role of Caveolae in Cellular Processes; Gastritis; FOS: Biological sciences; Medicine; Surgery; Microbiome; precancerous lesions; Precancerous Conditions; Research Article

In this study, a panel was established including differential metabolites, genera, and their interactions, which may help to discriminate high-risk subjects for progression from mild lesions to advanced precancerous lesions in short-term and long-term follow-up.