Age-related changes in microcirculation in the cortex of hypertonic rats

• DOI: 10.1134/s2079057017010143
• Publication Date: 2017-04-12T01:13:32Z
• Authors: I. B. Sokolova; I. V. Sergeev; O. R. Fedotova; N. N. Melnikova; D. P. Dvoretsky
• Keywords: Hypertonic saline; Oxygen Saturation

We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.