Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis.

• DOI: 10.1136/adc.72.1.16
• Publication Date: 2008-12-22T23:07:28Z
• Authors: S Young; P T O'Keeffe; J Arnott; L I Landau
• Keywords: Wheeze; Respiratory sounds; Atopy

Acute viral respiratory illness during infancy has been implicated as a precursor for subsequent lower morbidity in childhood. A prospective, longitudinal study of function, airway responsiveness, and early childhood was performed cohort 253 healthy infants to characterise those who experienced bronchiolitis. Seventeen (7% the cohort), were given diagnosis bronchiolitis first two years life with (1%) requiring hospital admission. Seventy one per cent had family history atopy, 53% asthma, 29% mother smoked cigarettes. These characteristics this group not different from rest cohort. There also no differences number older siblings, breast fed, duration feeding, or socioeconomic status families between that did get Respiratory function assessed at 1, 6, 12 months age. Maximum flow functional residual capacity (VmaxFRC) measured using rapid thoracic compression technique. Resistance (Rrs) size corrected compliance (Crs/kg) obtained single brief occlusion end inspiration. Airway responsiveness by histamine inhalation challenge provocation concentration resulting 40% fall on VmaxFRC baseline (PC40) determined. measurements ranked into terciles assess distribution developed through Cough wheeze noted be frequent before episode This demonstrated develop have evidence pre-existing reduced symptoms. It is proposed bronchiolitis, although potentially contributory, usually causative morbidity.