The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa

• DOI: 10.1136/adc.85.5.427
• Publication Date: 2002-07-27T10:32:19Z
• Authors: A Bakkaloglu
• Keywords: IIf; Polyarteritis Nodosa; Systemic vasculitis; Microscopic polyangiitis; Microscopic hematuria

<h3>AIMS</h3> To describe the distribution and features of classic polyarteritis nodosa (PAN) microscopic (MPA) importance antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. <h3>METHODS</h3> Classic PAN was diagnosed 15 patients based on presence aneurysms angiography 10 necrotising vasculitis medium sized arteries five. MPA patients, characteristic findings at renal biopsy six by small arteritis four. Serum ANCA detected initially indirect immunofluorescence (IIF) followed an immunoassay for myeloperoxidase (MPO) each case. <h3>RESULTS</h3> The median age with 12 (range 8–17) 9.5 5–14) respectively. None had failure. Six presented failure; four progressed to chronic Clinically evident pulmonary–renal syndrome present three MPA. IIF negative nine, showed mild staining patterns six, one MPO-ELISA mildly increased. revealed very strong perinuclear nine atypical one. In MPA, level 42.5 EU/ml 20–250). Treatment satisfactory effective treatment; however relapses did occur. <h3>CONCLUSION</h3> is useful diagnosis follow up