Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period

• DOI: 10.1136/ard.2007.073023
• Publication Date: 2007-08-30T00:48:25Z
• Authors: J-P Raynauld; J Martel-Pelletier; M-J Berthiaume; F Abram; D Choquette; B Haraoui; J F Beary; G A Cline; J M Meyer; J-P Pelletier
• Keywords: Knee cartilage

To evaluate in patients with knee osteoarthritis (OA) the size changes bone oedema and cysts over 24 months, to contrast these cartilage volume loss using quantitative magnetic resonance imaging.107 OA, selected from a large trial evaluating effect of bisphosphonate, were analysed by imaging at baseline months. Assessments subchondral cysts, done.At baseline, 86 showed presence least one type lesion: 71 oedema, 61 51 both. At although not statistically significant, total change increased 2.09 (SD 15.03) mm, cyst 1.09 (8.13) mm; mean for was +0.38 (2.18) mm -0.10 (4.36) cyst. When according subregions, an increase found trochlea (+0.67 (2.74) p = 0.02) lateral tibial plateau (+0.15 (0.83) 0.09), medial (+1.73 (8.11) 0.05). significant correlations seen between condyle (-0.40, 0.0001) (-0.23, 0.03), (-0.29, 0.01). A multivariate analysis that strongly independently associated (-0.31, 0.0004).These data demonstrate lesions are prevalent OA. The correlation compartment time greater this area underlines importance OA pathophysiology.