Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis.

• DOI: 10.1136/ard.49.6.354
• Publication Date: 2008-07-28T23:49:46Z
• Authors: A.S Taha; S McLaughlin; P.J Holland; R.W Kelly; R.D Sturrock; R.I Russell
• Keywords: Etodolac; Thromboxane B2

The synthesis of gastric and duodenal mucosal prostaglandin E2, I2, thromboxane B2 during a 60 minute incubation biopsy specimens, the degree endoscopic histological damage, anti-inflammatory response were all studied after four week, double blind study therapeutic doses two non-steroidal drugs, naproxen etodolac, received by 27 patients with active rheumatoid arthritis (13 receiving naproxen, 14 etodolac). Prostaglandin values treatment did not differ from baseline levels when analysed as one group. Subgroup analysis showed that suppressed E2 median 29 to 9 ng/mg protein, 34 11 ng/mg, I2 62 15 protein. No overall suppression occurred etodolac. Also, on second assessment had lower but higher B2, than Both drugs comparable anti-arthritic activity caused microscopic gastritis in similar proportions patients. correlation was detected between damage which developed seven (54%) three etodolac (21%). These findings indicate that, unlike does seem affect or synthesis; other mechanisms injury need be considered.