Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

• DOI: 10.1136/ard.62.11.1094
• Publication Date: 2003-10-28T18:51:57Z
• Authors: I Tchetverikov; L R Lard; J DeGroot; N Verzijl; J M TeKoppele; F C Breedveld; T W J Huizinga; R Hanemaaijer
• Keywords: Adult; Male; Middle Aged; Matrix Metalloproteinases; Statistics, Nonparametric; 3. Good health; Arthritis, Rheumatoid; 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Matrix Metalloproteinase 9; Disease Progression; Humans; Female; Joints; Matrix Metalloproteinase 3; alpha-Macroglobulins; Prospective Studies; Biomarkers

To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in alpha(2) macroglobulin (alpha(2)M)/MMP complexes progression joint destruction patients with recent onset rheumatoid arthritis (RA).109 RA were entered into this longitudinal study. Patients followed up for two years; clinical data, blood samples, radiographs obtained at baseline 1 2 years. Serum MMPs measured by sandwich ELISA MMP assays.During years damage progressed from 0 to 10 (median Sharp score, p<0.001). Stable pro-MMP-3 a significant decrease pro-MMP-8 alpha(2)M/MMP seen throughout Regression analysis showed that serum disease independently associated (B=0.7, 95% CI 0.3 1.1, p=0.001). Based on rate destruction, divided subgroups: mild severe progression. The significantly higher group compared all times. Levels decreased both groups, whereas complex only.Serum studied are activity, but also predictive