Assessment of oxygen extraction rate changes following red blood cell transfusion in the intensive care unit: a protocol for a prospective observational non-interventional study

• DOI: 10.1136/bmjopen-2023-074413
• Publication Date: 2024-02-15T03:34:54Z
• Authors: Ahmet Salih Tüzen; Murat Aksun; Atilla Sencan; Senem Girgin; Birzat Emre Gölboyu; Gizem Kırbaş; Ozan Şanlı
• Keywords: Institutional review board

Haemoglobin transfusion thresholds have been used in the intensive care unit (ICU) to guide red blood cell (RBCT) decisions. Recent research has also focused on physiological indicators of tissue oxygenation as trigger points for transfusion. This study aims assess oxygen extraction rate (O2ER) a critical indicator delivery-consumption balance tissues and investigate its potential reliable ICU patients by analysing clinical outcomes. The utilisation may expedite decision-making process RBCT requiring immediate intervention, while simultaneously minimising risks associated with unnecessary transfusions.This prospective, single-centre, observational cohort will include 65 undergoing RBCT. We evaluate essential markers such arterial content, central venous arteriovenous difference, O2ER near-infrared spectroscopy before 15 min after primary outcome is percentage increase between two groups relative initial level. Secondary outcomes complications patient relation baseline O2ER. A 90-day comprehensive follow-up period be implemented all enrolled patients.This obtained ethics committee approval from Izmir Katip Celebi University Non-Interventional Clinical Studies Institutional Review Board. Written informed consent their enrolment study. findings disseminated through publication peer-reviewed journals presentation at national or international conferences.NCT05798130.