Trade-offs between overall survival and side effects in the treatment of metastatic breast cancer: eliciting preferences of patients with primary and metastatic breast cancer using a discrete choice experiment

• DOI: 10.1136/bmjopen-2023-076798
• Publication Date: 2024-04-29T07:00:11Z
• Authors: Alistair Bullen; Mandy Ryan; Holly Ennis; Ewan Gray; Luis Enrique Lorí...; Morag McIntyre; Peter Hall
• Keywords: Adult; Supplementary Information; 610; Breast Neoplasms; R Medicine; 613; Choice Behavior; decision making; 03 medical and health sciences; Health Economics; 0302 clinical medicine; SDG 3 - Good Health and Well-being; shared; Humans; Neoplasm Metastasis; Aged; R; SC007342; Patient Preference; Middle Aged; United Kingdom; quality of life; surveys and questionnaires; Medicine; Female; Other; Breast neoplasms; patient preference

There has been a recent proliferation in treatment options for patients with metastatic breast cancer. Such treatments often involve trade-offs between overall survival and side effects. Our study aims to estimate the that could be used inform decision-making at individual policy level. We designed discrete choice experiment (DCE) look preferences avoiding severity levels of effects when choosing Treatment attributes were: fatigue, nausea, diarrhoea, other (peripheral neuropathy, hand-foot syndrome mucositis) urgent hospital admission survival. Responses were analysed using an error component logit model. estimated relative importance minimum acceptable improvements The DCE was completed online by UK residents self-reported diagnoses 105 respondents participated, which 72 had cancer 33 primary Overall largest importance, followed effects, nausea fatigue. risk not significant. While most important attribute, willing forgo some absolute probability reductions all Grade 2 (12.02% syndrome, 11.01% mucositis, 10.42% peripheral 6.33% diarrhoea 3.62% nausea). 1 significant, suggesting have general tolerance them. Patients are avoid particular results implications data collected research studies can help person-centred care shared decision-making.