Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans.

• DOI: 10.1136/gut.40.5.575
• Publication Date: 2014-08-18T18:06:44Z
• Authors: J Boulant; S Mathieu; M D'Amato; A Abergel; M Dapoigny; G Bommelaer
• Keywords: Gastric distension; Barostat; Proglumide; Gastrointestinal hormone

BACKGROUND AND AIMS: Transient lower oesophageal sphincter relaxations (TLOSRs) has been found to be the main mechanism of gastro-oesophageal reflux. In dogs, cholecystokinin (CCK) is involved in their occurrence. The aim was evaluate role endogenous and exogenous CCK occurrence TLOSRs induced by gastric distension at constant pressure humans. METHODS: Ten healthy volunteers were studied. Lower monitored with a sleeve device performed via an intragastric bag barostat. During distensions, saline, (30 ng/kg/h) or CCK-A receptor antagonist loxiglumide (10 mg/kg/h) perfused random double blind order. RESULTS: There no significant difference between number during different distensions saline; increased mean rate 13.1 compared 9.1 saline (p < 0.001). Loxiglumide significantly decreased 5.3 versus 8.3 under paired infusion CONCLUSIONS: humans, subtype transient distension.