Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis?

• DOI: 10.1136/gut.45.6.818
• Publication Date: 2010-06-30T16:46:12Z
• Authors: K Konishi; T Fujii; N Boku; S Kato; I Koba; A Ohtsu; H Tajiri; A Ochiai; S Yoshida
• Keywords: Histology; Mucosal lesions; Distal colon; Ascending colon

<h3>BACKGROUND</h3> There is a difference in the location of colorectal mucosal lesions and invasive cancers. <h3>AIMS</h3> To ascertain whether neoplasms reflects carcinogenesis pathway. <h3>METHODS</h3> The subject material consisted 4147 neoplastic that had been resected endoscopically or surgically from 5025 patients. Mucosal submucosal cancers were classified into depressed non-depressed types histologically. relations between macroscopic type, size, histology, investigated. <h3>RESULTS</h3> (<i>a</i>) Non-depressed type. A total 1774 3454 (51%) located right colon, 1212 (35%) left 468 (14%) rectum. incidence larger than 10 mm was 10% (185/1774) 21% (254/1212) 27% (127/468) with villous components 2% (32/1774) 5% (63/1212) 13% (62/468) ratio to significantly higher rectum (0.064, 30/469) (0.034, 43/1279) (0.010, 18/1857) colon. (<i>b</i>) Depressed incidences type (83/1857) 17% (3/18) (67/1279) (2/43) 0.2% (1/469) 0% (0/30) rectum, respectively. <h3>CONCLUSION</h3> may be some mechanisms promote progression colon whereas de novo pathway implicated