IDDF2024-ABS-0441 Exploring the gut-thyroid axis: dietary deficiencies and gene expression patterns in pediatric patients with thyroid disorders

• DOI: 10.1136/gutjnl-2024-iddf.157
• Publication Date: 2024-08-12T15:15:36Z
• Authors: Ritika Shrivastava; Ashish Mudgal; Nandini Nanda; Chaiwang Konyak; Megh Singh Dhakad; Aashima Dabas; Sonal Saxena; Binita Goswami

<h3>Background</h3> This study aims to investigate the interplay between gut health, thyroid disease, and dietary intake of key nutrients (kcals, zinc, iron) in pediatric patients. Specifically, we aimed analyze expression genes related iodine metabolism, hormone synthesis, barrier function, host-microbiome interactions relation deficiencies. <h3>Methods</h3> Stool samples were collected from 20 patients diagnosed with nucleic acids extracted for genetic analysis. Additionally, kcals, iron was assessed through records. qPCR PCR techniques employed target specific involved metabolism (NIS, TPO), synthesis (TG, TR), function (ZO-1, Occludin), inflammatory markers (TNF-α, IL-6), interaction (TLRs, AMPs), signaling (GLP-1R, GIPR). Statistical analyses conducted correlate gene levels deficiencies disease severity. <h3>Results</h3> Our initial examination uncovered notable caloric intake, among subjects. Analysis patterns revealed disturbances associated function. changes NIS TPO observed, which correlated inadequate iodine, iron. variations detected ZO-1 Occludin, suggesting possible compromises intestinal integrity disorders insufficiencies. <h3>Conclusions</h3> The findings suggest a complex Dietary may exacerbate dysregulation potentially impacting Moreover, alterations highlight role health. Future studies should explore interventions targeting optimization health maintenance improve outcomes populations.