196 The relationship of physical activity, heart rate variability, and night heart rate to established measures of clinical risk in patients with pulmonary arterial hypertension (pah)

• DOI: 10.1136/heartjnl-2023-bcs.196
• Publication Date: 2023-07-17T12:59:27Z
• Authors: Junaid Patel; David G Kiely; Chloe Roddis; Athanasios Charal...; Roger Thompson; Charlotte Pearson; Jennifer Dick; Sarah Binmahfooz; Robert Lewis; Jake Taylor; Cameron Ashraf; Krit Dwivdi; Jennifer Tegan Mi...; Andy J Swift; Judith Hurdman; Charlotte Durrington; Robin Condliffe; Lisa Watson; Stefan Roman; Alexander M K Rot...; Ashwin Reddy; Iain Armstrong; Hamza Zafar; Abdul Hameed; Neil Hamilton; Charlie Elliot; Jenna Ablott; Frances Varian; Mark Toshner; Dharshan Neelam-N...; Christian Battersby

<h3>Introduction</h3> Exercise capacity is used for risk stratification in patients with pulmonary arterial hypertension (PAH) and the evaluation of clinical efficacy studies, however, this requires a hospital-based assessment. Physical activity, measured remotely, has been implemented studies as an indicator exercise capacity. The relationships between daily physical activity established measures are unknown. <h3>Methods</h3> Participants PAH enrolled National Cohort Study Idiopathic Heritable (NAIAD, NCT01907295) were implanted insertable cardiac monitor (ICM, LinQ- Medtronic), which provided remote measure from embedded single axis accelerometer. Baseline indicators including WHO Functional Class (WHO FC)2,3, NTproBNP2,3, 6 Minute Walk Distance (6MWD)2,3, Incremental Shuttle test (ISWD)2, COMPERA 2.03 EmPHasis-104 compared heart rate variability (HRV), night (NHR). <h3>Results</h3> demographics (mean±SD): idiopathic or heritable (n=80); age 53±15 years; female sex 75.9%; BMI 30±7kg/m²; years since diagnosis 8.1±5.3, baseline resting 75.1±12.2 beats per minute. Patients within low-risk COMPERA2.0 category reference group. Table 1 shows statistically significant NHR, HRV to (p&lt;0.05). ICM-measured showed higher sensitivity distinguishing low-intermediate, intermediate, intermediate-high groups across FC, 2.0 NTProBNP. 2 demonstrates that was reduced those intermediate high-risk low group (WHO-FC, ISWD. NT-proBNP, EmPHasis-10 score). increased by ISWD (figure 2, table 2). <h3>Conclusion</h3> data, NHR correlates existing may be PAH. <h3>Conflict Interest</h3> None