Exercise duration as a determinant of vascular function and antioxidant balance in patients with coronary artery disease

• DOI: 10.1136/hrt.2010.209080
• Publication Date: 2011-02-26T03:10:04Z
• Authors: A. P. Michaelides; D. Soulis; C. Antoniades; A. S. Antonopoulos; A. Miliou; N. Ioakeimidis; E. Chatzistamatiou; C. Bakogiannis; K. Marinou; C. Liakos; C. Stefanadis
• Keywords: Male; Cross-Over Studies; Superoxide Dismutase; Coronary Artery Disease; Walking; Middle Aged; Antioxidants; Elasticity; 796; Exercise Therapy; 03 medical and health sciences; Superoxide Dismutase-1; 0302 clinical medicine; Malondialdehyde; Humans; Vascular Resistance; Exercise; Blood Flow Velocity; Aged

<h3>Background</h3> Exercise improves the clinical outcome of patients with coronary artery disease (CAD); however, ideal exercise duration for each patient remains unclear. <h3>Objective</h3> To investigate effects on arterial elastic properties and antioxidant/pro-oxidant mechanisms in CAD. <h3>Design, setting, patients, interventions</h3> Sixty male CAD were randomised into two groups, underwent 30 min or 60 a crossover design 2 weeks9 wash-out period. In all participants aortic radial blood pressures (BP) (augmentation index (AIx)/pulse wave velocity (PWV)) determined at baseline 24 h after exercise. Plasma malonyldialdehyde (MDA) superoxide dismutase (SOD)1 SOD2 levels also measured. <h3>Results</h3> had no effect BP (p=NS all). Walking 30min improved AIx (from 33.79±0.91% to 31.73±0.86%, p&lt;0.001) PWV 9.26±0.95m/s 9.06± 0.21m/s, p&lt;0.001), while 60min adverse vascular stiffness (for AIx: from 33.37± 0.93% 33.73± 1.05%, p=NS PWV: 9.25±0.19m/s 9.37±0.21m/s, p&lt;0.05 mainly older patients). was associated significant 20% increase MDA (p&lt;0.05). SOD1 levels, however it significantly increased 2.26±0.22ng/mL 2.36±0.18ng/mL, p&lt;0.05) but not (p=NS). <h3>Conclusion</h3> Shorter favourable antioxidant effects, longer blunted these beneficial accompanied by function, patients. Further studies are required explore hypothesis that more individualised approach selection appropriate programme should be considered