Association of weight change in different periods of adulthood with risk of type 2 diabetes in Japanese men and women: the Japan Public Health Center-Based Prospective Study

• DOI: 10.1136/jech.2009.097964
• Publication Date: 2010-07-13T22:26:07Z
• Authors: A. Nanri; T. Mizoue; Y. Takahashi; Y. Matsushita; M. Noda; M. Inoue; S. Tsugane
• Keywords: Weight change

<h3>Background</h3> Few studies have examined the impact of weight change in different periods lifetime on type 2 diabetes risk, and association loss with is unclear. We prospectively investigated since age 20 y that during middle-to-late adulthood incidence diabetes. <h3>Methods</h3> Subjects were 52 014 men women aged 45–75 who participated Japan Public Health Center-Based Prospective Study had no history ORs self-reported physician-diagnosed for between baseline survey (mean 50.6 y) 5 second surveys estimated using logistic regression analysis. <h3>Results</h3> During 5-year period following survey, 989 newly diagnosed cases self-reported. Weight gain from was associated an increased risk The multivariate-adjusted OR (95% CI) a ≥5 kg versus stable 2.61 (2.11 to 3.23) 2.56 (1.95 3.35) women. A over 5-y also No observed either period. <h3>Conclusions</h3> These results suggest long-term early middle-age increases further enhanced by later life