ACE2andTMPRSS2expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19

• DOI: 10.1136/jitc-2020-001020
• Publication Date: 2020-07-16T10:55:29Z
• Authors: Riyue Bao; Kyle Hernandez; Lei Huang; Jason John Luke
• Keywords: TMPRSS2

Pandemic COVID-19 by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection is facilitated the ACE2 receptor and protease TMPRSS2. Modestly sized case series have described clinical factors associated with COVID-19, while TMPRSS2 expression analyses been in some cell types. Patients cancer may worse outcomes to COVID-19.We performed an integrated study of gene across within organ systems, normal versus tumor, several existing databases (The Cancer Genome Atlas, Census Immune Single Cell Expression The Human Landscape, more). We correlated (including but not limited age, gender, race, body mass index, smoking history), HLA genotype, immune patterns, subsets, single-cell sequencing as well commensal microbiome.Matched tissues generally display higher compared cancer, tumor from digestive organs expressing highest levels. No were consistently identified be significantly levels though outlier systems observed for factors. Similarly, no genotypes Strong correlations between multiple signatures including interferon-stimulated genes T cell-inflamed phenotype inverse associations angiogenesis transforming growth factor-β signatures. positively macrophage subsets was less strongly epithelial abundance. Single-cell analysis nine independent studies demonstrated little or lymphocytes macrophages. microbiota matched particularly colorectal cancers, distinct bacterial populations showing strong associations.We a large-scale integration clinical, genetic, microbiome domains. identify novel confirm host immunity expression. suggest caution interpretation regarding genetic suggested smaller series.