Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model

• DOI: 10.1136/jitc-2023-008491
• Publication Date: 2024-05-23T16:55:25Z
• Authors: Zhenqiang Sun; Yanxin Xu; Bo Shao; Pengyuan Dang; Shengyun Hu; Haifeng Sun; Chen Chen; Chaoguan Wang; Jinbo Liu; Yang Liu; Junhong Hu
• Keywords: Macrophage polarization; M2 Macrophage; Tumor-associated macrophage; Exosome

Background Accumulating evidence demonstrates that an increased tumor-associated macrophage abundance is often associated with poor prognosis in colorectal cancer (CRC). The mechanism underlying the effect of tumor-derived exosomes on M2 polarization remains elusive. Results novel circular RNA circPOLQ exhibited significantly higher expression CRC tissues than paired normal tissues. Higher was poorer patients CRC. In vitro and vivo experiments showed exosomal did not directly regulate cell development but promoted metastatic nodule formation by enhancing polarization. activated interleukin-10/signal transducer activator transcription 3 axis targeting miR-379–3 p to promote Conclusion can enter macrophages via cell-derived These findings reveal a exosome-mediated tumor–macrophage interaction potentially affecting formation.