274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency

• DOI: 10.1136/jitc-2023-sitc2023.0274
• Publication Date: 2023-10-31T13:48:37Z
• Authors: Demetrios Kalaitz...; Mohammed Ghonime; Robert Chain; Nivedita Jaishankar; Davis Settipane; Zinkal Padalia; Lauren Zakas; Meghna Kuppuraju; Paul Tetteh; Mary-Lee Dequeant; Sushant Karnik; Chandirasegaran M...; Brigid McEwan; Henia Dar; Melanie Allen; Laura Serwer; Thao Nguyen; Melanie Butler-Ga...; Parin Sripakdeevong; Shashwat Nagar; Yin Tang; Nicole Flanagan; Elaine Huang; Shashwant Phuyal; Andrew Dunn; Elizabeth Koch; Erisa Sula; Jacob Waldman; Maria Lei Zhang; Cristian Loaiza; Erin Thorstensen; Keith Steiger; Katie Schum; Kayla Urbaez; Anna Ma; Annie Yang Weaver; Christopher Finch; Sarah Cohen; PK Morrow; Mark Benton; Jonathan Terrett
• Keywords: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282