Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke

• DOI: 10.1136/jnnp-2020-323522
• Publication Date: 2020-07-20T14:55:24Z
• Authors: Fadi Al Saiegh; Ritam Ghosh; Adam Leibold; Michael B Avery; Richard F Schmidt; Thana Theofanis; Nikolaos Mouchtouris; Lucas Philipp; Stephen C Peiper; Zi-Xuan Wang; Fred Rincon; Stavropoula I Tjo...; Pascal Jabbour; Robert H Rosenwasser; M. Reid Gooch
• Keywords: Stroke; Pandemic

Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to COVID-19 pandemic. The extent involvement central nervous system is not well established, and presence or absence SARS-CoV-2 particles cerebrospinal fluid (CSF) a topic debate.We present two patients with concurrent neurological symptoms. Our first patient 31-year-old man who had flu-like symptoms due later developed an acute-onset severe headache loss consciousness was diagnosed Hunt Hess grade 3 subarachnoid haemorrhage from ruptured aneurysm. second 62-year-old woman ischaemic stroke massive haemorrhagic conversion requiring decompressive hemicraniectomy. Both patients' CSF repeatedly negative on real-time PCR analysis despite disease.Our report shows that may be devoid viral even when they test positive for nasal swab. Whether depend systemic disease severity degree virus' tissue tropism should examined future studies.