Addressing the gender divide: managing idiopathic Parkinson’s disease in the menopausal and peri-menopausal population

• DOI: 10.1136/jnnp-2023-abn.111
• Publication Date: 2023-11-23T12:40:47Z
• Authors: Bunting Eva; Bryant Jayne; Saha Romi
• Keywords: Peri

<h3></h3> Idiopathic Parkinson's disease (IPD) is more common in men than women, with a relative risk 1.5 times greater males[1]. Additionally, IPD tends to present later women [2, 3] and progress slowly, as females are likely the tremor-dominant PD phenotype[2]. Attempts have been made establish if female gonadal hormones explain these observed differences, exerting neuro-protective effect on dopaminergic transmission neuronal degeneration, however results inconsistent [4]. There shared symptomatology between menopausal individuals, further one may serve exacerbate other. We will survey of perimenopausal patients IPD, summarising rates Hormone Replacement Therapy (HRT) use, its perceived effects wellbeing, including symptoms any barriers accessing treatment. In Sussex, we collaborated local GP's menopause specialists develop guidance which aims improve access HRT for IPD. suggest that threshold at therapy offered should be lower general population. hope sharing our experience help neurologists navigate this evolving field.