Cerebral correlates of declarative memory dysfunctions in early traumatic brain injury

• DOI: 10.1136/jnnp.2004.027631
• Publication Date: 2004-12-17T02:13:06Z
• Authors: J M Serra-Grabulosa
• Keywords: Memory Impairment; Grey matter

We investigated residual brain damage in subjects who suffered severe traumatic injury (TBI) childhood, and its relationship with declarative memory impairment. Magnetic resonance imaging (MRI) volumetric data performance were compared between 16 adolescents antecedents of TBI matched normal controls. Volumes grey matter, white cerebrospinal fluid (CSF), hippocampus, caudate nuclei measured. Verbal was assessed by the Rey's Auditory Learning test visual Complex Figure. patients performed significantly worse than controls both verbal memory. Patients presented decreased matter volume increased CSF. The hippocampus reduced, but not nuclei. Memory correlated Plasticity is incomplete for structural functional deficits children TBI. Hippocampal atrophy, loss, impairment remain until adolescence. sequelae are related more to diffuse injury, as reflected MRI findings CSF, hippocampal injury.