Unilateral brain damage after prolonged hemiconvulsions in the elderly associated with theophylline administration.

• DOI: 10.1136/jnnp.55.6.466
• Publication Date: 2008-11-10T22:20:59Z
• Authors: H Mori; T Mizutani; M Yoshimura; H Yamanouchi; H Shimada
• Keywords: Brain damage; Cerebral hemisphere

The brains of 14 elderly patients who died after status epilepticus were examined pathologically. Three the showed unilateral brain damage which corresponded to side seizures, and lesions thought be caused by seizures. In these three two other patients, no causative lesion related seizures was found. five occurred during theophylline therapy thus in assumed induced theophylline. with damage, seen hippocampus, amygdala thalamus while third, whole hemisphere damaged, including amygdala, thalamus, basal ganglia cerebral cortex. distribution pathological changes within described. It is suggested that primarily affected rather than secondary degeneration from