Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis?

• DOI: 10.1136/openhrt-2020-001346
• Publication Date: 2020-10-13T21:05:59Z
• Authors: Aénora Roger-Rollé; Eve Cariou; Khailène Rguez; Pauline Fournier; Yoan Lavie-Badie; Virginie Blanchard; Jérôme Roncalli; Michel Galinier; Didier Carrié; Olivier Lairez
• Keywords: Male; Ventricular Function, Left; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Diseases of the circulatory (Cardiovascular) system; Humans; Heart Failure and Cardiomyopathies; Aged; Retrospective Studies; Aged, 80 and over; Observer Variation; Reproducibility of Results; Stroke Volume; Amyloidosis; Middle Aged; Prognosis; Myocardial Contraction; Echocardiography, Doppler; 3. Good health; RC666-701; Exercise Test; Female; Cardiomyopathies; Echocardiography, Stress

Background Cardiac amyloidosis (CA) is a life-threatening restrictive cardiomyopathy. Identifying patients with poor prognosis essential to ensure appropriate care. The aim of this study was compare myocardial work (MW) indices standard echocardiographic parameters in predicting mortality among CA. Methods Clinical, biological and transthoracic were retrospectively compared 118 Global index (GWI) calculated as the area left ventricular pressure–strain loop. efficiency (GWE) defined percentage ratio constructive sum wasted works. Sixty-one (52%) performed cardiopulmonary exercise. Results GWI, GWE, global longitudinal strain (GLS), ejection fraction (LVEF) contraction (MCF) correlated N-terminal prohormone brain natriuretic peptide (R=−0.518, R=−0.383, R=−0.553, R=−0.382 R=−0.336, respectively; p<0.001). GWI GLS peak oxygen consumption (R=0.359 R=0.313, p<0.05). Twenty-eight (24%) died during median follow-up 11 (4–19) months. best cut-off values predict all-cause for GLS, LVEF MCF 937 mm Hg/%, 89%, 10%, 52% 15%, respectively. under receiver operator characteristic curve 0.689, 0.631, 0.626, 0.511 0.504, Conclusion In CA population, MW are well known markers better than mortality. However, does not perform GLS.