Grey matter abnormality in progressive multifocal leucoencephalopathy

• DOI: 10.1136/practneurol-2020-002852
• Publication Date: 2021-03-30T17:20:38Z
• Authors: Christopher Yuki ...; Han Sung Lee; Alan Howe Yee
• Keywords: Adult; Leukoencephalopathy, Progressive Multifocal; Neuroimaging; JC Virus; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; DNA, Viral; Humans; Female; Gray Matter

Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard is demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey matter involvement on neuroimaging. Here we describe the histopathological correlate of cerebral grey matter involvement and radiological accompaniment in a patient with biopsy proven PML.