Serum calprotectin (S100A8/A9): a promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis

• DOI: 10.1136/rmdopen-2021-001646
• Publication Date: 2022-11-17T15:11:18Z
• Authors: Céline La; Phu Quoc Lê; Alina Ferster; Laurence Goffin; Delphine Spruyt; Bernard Lauwerys; Patrick Durez; Cecile Boulanger; Tatiana Sokolova; Joanne Rasschaert; Valérie Badot
• Keywords: Oligoarthritis; Erythrocyte sedimentation rate; S100A8

Introduction In the management of juvenile idiopathic arthritis (JIA), there is a lack diagnostic and prognostic biomarkers. This study assesses use serum calprotectin (sCal) as marker to monitor disease activity, classification prognosis tool response treatment or risk flares in patients with JIA. Methods Eighty-one JIA from CAP48 multicentric cohort were included this study, well 11 non-paediatric healthy controls. An ELISA method was used quantify sCal commercial kit. Results Patients an active compared controls inactive showed eightfold twofold increased level sCal, respectively. found be correlated C-reactive protein (CRP) even more strongly erythrocyte sedimentation rate. Evolution DAS28 scores evolution opposed CRP. With regard CRP, could differentiate forms oligoarthritis polyarthritis systemic forms. However, brought added value CRP marker. Indeed, reaching minimal activity (according Juvenile Arthritis Disease Activity Score) at 6 months following test had higher levels, while levels if flare observed up 3–9 test. Conclusions confirms potential uses biomarker diagnosis follow-up