Fluorescence-optical imaging as a promising easy-to-use imaging biomarker to increase early psoriatic arthritis detection in patients with psoriasis: a cross-sectional cohort study with follow-up

• DOI: 10.1136/rmdopen-2022-002682
• Publication Date: 2022-12-06T14:37:34Z
• Authors: Michaela Koehm; Sarah Ohrndorf; Ann C Foldenauer; Tanja Rossmanith; Marina Backhaus; Stephanie G Werner; Gerd R Burmester; Siegfried Wassenberg; Benjamin Koehler; Harald Burkhardt; Frank Behrens
• Keywords: Adult; Arthritis, Psoriatic; Optical Imaging; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Spondyloarthritis; Humans; Psoriasis; Prospective Studies; Follow-Up Studies

Objectives To evaluate the ability of fluorescence-optical imaging (FOI) to detect preclinical musculoskeletal inflammatory signs in patients with skin psoriasis at risk developing psoriatic arthritis (PsA). Methods This investigator-initiated prospective exploratory study evaluated adult complaints and/or nail within last 6 months. Patients underwent a comprehensive rheumatological clinical examination (CE) along ultrasound (MSUS) and FOI both hands single visit. CE–/MSUS–/FOI+ findings had MRI performed on symptomatic or dominant hand 7 days. If was negative, were followed over 2 years for onset clinically manifest PsA. Results A total 389 referred from dermatology centres 14 rheumatology sites Germany. Seventy-seven (20%) CE−/US−/FOI− considered have only. PsA diagnosed 140/389 (36%) based CE alone another 55 (14%) by additional MSUS; overall, 50% patient cohort One hundred sixteen (30%) FOI+ (CE−) which 40 (37%) FOI+/MRI+. In 2-year follow-up FOI+/CE− patients, confirmed 12%. Conclusion is promising method detection inflammation that may serve as an early biomarker transitions technique has potential at-risk psoriasis, reduce time diagnosis improve outcomes.