Impact of patient ancestry on heterogeneity of Sjögren’s disease

• DOI: 10.1136/rmdopen-2022-002955
• Publication Date: 2023-03-16T10:22:34Z
• Authors: Maxime Beydon; Raphaele Seror; Véronique Le Guern; Pascale Chretien; Xavier Mariette; Gaetane Nocturne
• Keywords: Adult; Sjogren's Syndrome; [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system; Case-Control Studies; Arthritis; Antibodies, Antinuclear; R; Medicine; Humans; Middle Aged; Connective Tissue Diseases; 3. Good health; Retrospective Studies

We aimed to compare disease characteristics between primary Sjögren's syndrome (pSS) patients of African ancestry (AA) and Caucasian ancestry.We conducted a retrospective, case-control study in French national European referral centre for pSS. All with pSS AA were matched two Caucasians having similar follow-up duration. explored clinical biological parameters associated cumulative EULAR Syndrome Disease Activity Index (cumESSDAI ≥5) (consisting individual clinESSDAI domain maximum throughout follow-up).We identified 74 148 Caucasian. Median age at diagnosis was younger (43 years (IQR 33-51) vs 56 (44.8-59.2), p<0.001). presented higher median titre gammaglobulins (18.5 g/L 15-22.8) 13.4 (9.9-16.9), p<0.001), more frequently positive anti-SSA (88% 72%, p=0.007) anti-RNP (11% 2.7%, p=0.023) antibodies. During the (median: 6 2-11)), systemic complications: arthritis, myositis, interstitial lung disease, lymphadenopathy, central nervous system involvement. cumESSDAI score (7.5 3.2-16.0) 4.0 2.0-9.0), p=0.002). Interestingly, multivariate analyses, factors activity sub-Saharan (OR 2.65 (95% CI 1.06 6.94)), rheumatoid factor 2.50 1.28 4.96)) positivity 11.1 1.88 212)).Patients display hallmark B-cell activation. Studies investigate drivers behind such differences are needed.