Anticitrullinated peptide antibody epitope expansion and the HLA DRB1 ‘shared epitope’ are less common in seropositive checkpoint inhibitor-induced inflammatory arthritis than in longstanding rheumatoid arthritis

• DOI: 10.1136/rmdopen-2023-003012
• Publication Date: 2023-06-24T05:16:24Z
• Authors: Nilasha Ghosh; Pankti Reid; Carlos Andres Aude; Jessica Kirschman; Susan Goodman; Vivian P Bykerk; Amit Lakhanpal; Diviya Rajesh; Karmela K Chan; William H Robinson; Anne R Bass
• Keywords: Inflammatory arthritis

Immune checkpoint inhibitors (ICI) can potentially cause ICI-inflammatory arthritis (ICI-IA), which often resembles rheumatoid (RA). In this study, we examined the degree of anticitrullinated peptide antibodies (ACPA) epitope expansion in CCP+ICI-IA and patients with RA.