Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity

• DOI: 10.1136/rmdopen-2023-003486
• Publication Date: 2024-01-12T17:20:47Z
• Authors: Karen Holten; Nina Paulshus Sun...; Joseph Sexton; Lena Bugge Nordberg; Till Uhlig; Tore K Kvien; Daniel H Solomon; Espen A Haavardsholm; Siri Lillegraven; Anna-Birgitte Aga
• Keywords: Flare

Objectives To explore the performance of EULAR-initiated patient-reported Rheumatoid Arthritis Impact Disease (RAID) questionnaire in relation to flares disease activity, including comparison with other activity outcomes. Methods Patients rheumatoid arthritis sustained remission were randomised continued stable treatment or tapering ARCTIC REWIND project. In patients within 12 months, we compared RAID (total score and components) at flare visit prior following flare, using Wilcoxon signed-rank test. Similar analyses performed for patient global assessment, Activity Score (DAS) C reactive protein (CRP). The discriminative accuracies RAID, DAS CRP respect assessed by receiver operating characteristic (ROC) based on logistic regression models. Flare was defined as a combination >1.6, increase ≥0.6 ≥two swollen joints (of 44 examined) could be recorded if rheumatologist agreed that clinically significant had occurred. Results total, 248 included analyses, 56 flares. all changed significantly visits related (p<0.001). Area under curve (95% CI) values indicated (0.88 (0.83 0.93)) more accurate than (0.76 (0.69 0.84)) discriminating less assessment (0.92 (0.87 0.97)) (0.94 (0.90 0.98)). components highest lowest pain (0.91 (0.86 0.95)) sleep (0.59 0.79)). Conclusion associated median supporting its ability respond flare. Trial registration number NCT01881308 .