Ten-year follow-up investigation of stroke risk in systemic lupus erythematosus

• DOI: 10.1136/svn-2022-001499
• Publication Date: 2023-05-11T14:05:12Z
• Authors: Jin-An Huang; Ching-Heng Lin; Ming-Ju Wu; Yi-Hsing Chen; Kuo-Cheng Chang; Chung-Wei Hou
• Keywords: Stroke; Ischaemic stroke; Cumulative incidence

Background and purpose To analyse the long-term risk of ischaemic stroke clinical effects antithrombotics on haemorrhagic in patients with systemic lupus erythematosus (SLE). Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research Database. Patients SLE between 2000 2008 were registered matched two controls by index date, age, gender Charlson Comorbidity Index (CCI). These subjects followed until either event or 31 December 2013. Adjusted HRs (aHRs) for strokes estimated Cox regression models, cumulative incidence analysed log-rank test Kaplan-Meier survival analysis. Results In total, 8310 16 620 without included. general, had higher rates (5.4% vs 3.3%) (1.5% 0.6%) than controls. multivariate analysis adjusted to gender, CCI, urbanisation level uses, aHRs all strokes, 1.73 (95% CI: 1.54 1.94), 1.65 1.45 1.87) 2.24 1.71 2.95), respectively, SLE. significantly more likely suffer SLE, even 10 years after diagnosis (6.12% 3.50%, p<0.001). Antiplatelet use increased group (aHR=1.74, 95% 1.18 2.57). Conclusions are at greater developing that lasts years. Antiplatelets should be carefully administered prevent cardiovascular events due stroke.